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Developing safe, surgically practical regenerative materials requires understanding the mechanisms of cell-material interactions. Our previous work identified a novel nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) material inspired by the extracellular matrix that can induce calvarial bone healing in the absence of exogenous growth factors. Michelle K Oberoi @_moberoi and her co-authors from the UCLA Division of Plastic and Reconstructive Surgery evaluated the necessity of the Wnt pathways for the activity of MC-GAG in relationship to differences in stiffness. She and her co-authors showed that the osteogenic properties imparted by the stiffness of MC-GAG functions through the Wnt signaling pathways, such that inhibition downregulates YAP/TAZ expression, mineralization, and expression of bone markers. This mechanistic understanding of regenerative materials is required for safe clinical translation and development of next generation materials. Stiffness Of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis Via Mechanotransduction And Canonical Wnt Signaling Michelle K Oberoi, BS, BA @_moberoi; Justine C. Lee, MD, PhD @drjustineleemd Division of Plastic and Reconstructive Surgery, University of California, Los Angeles . . . #researchiscool #PSRC2021 #PSRCvirtualmeeting #virtualabstract #plasticsurgery #academicplasticsurgery #craniofacialsurgery #regeneration #regenerativemedicine #outcomes #research #researchiscool

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