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Staged implant-based breast reconstruction with immediate tissue expanders is the most common method of breast reconstruction after mastectomy. Tissue expanders traditionally are filled with saline for expansion. Recently, tissue expanders have been frequently placed in the prepectoral plane. Anecdotally, some surgeons have advocated initial intraoperative fill of the tissue expander with air to avoid excess pressure on ischemic mastectomy skin flaps. The purpose of this study was to evaluate the outcomes associated with breast reconstruction with immediate air versus saline tissue expander placement. #BreastReconstruction #TissueExpander #Prepec #InitialFill #Air #Saline

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