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Breast cancer is the second leading cause of death from cancer in women, projected to account for over 42,000 deaths in 2020. Due to its high burden of disease, innovations in breast cancer modeling are crucial to improving our understanding of its etiology as well as developing novel treatments. Currently, there are significant limitations to the two-dimensional (2D) and three-dimensional (3D) culture systems used to replicate and grow tumor cells, as the culture methods are often far removed from the complex ecosystems cells experience in native tissues. Understanding the limitations of prior models, our study proposes an innovative biomimetic platform that is able to more closely replicate the in vivo breast tumor microenvironment.

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