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Central nervous system sensitization is one of the major contributors of treatment failure in neuroma-induced neuropathic pain. Previous studies have shown that underlying hypersensitization mechanisms are different between males and females which warrants individualized and gender based therapeutics for pain management. Amir Dehdashtian @amir.dehdashtian and his co-authors from the University of Michigan, found that prophylactic regenerative peripheral nerve interface (RPNI) attenuates neuroma site pain and mechanical allodynia in both genders, however, thermal allodynia is attenuated in males only. Consistent with the behavioral testing, prophylactic RPNI treatment attenuated both macrophage proliferation in the DRGs, as well as microglial expansion in the dorsal horn of the spinal cord in males exclusively. Amir Dehdashtian, M.D., M.P.H @amir.dehdashtian, Shelby R. Svientek @shelbysvientek, MD, Mary Jane Risch, BS, Allison B. Vittert, BS, Jagienka H. Timek, BS, Daniel C. Ursu, PhD, Paul S. Cederna @paulcederna, MD, Stephen WP Kemp, PhD. Section of plastic surgery, University of Michigan, Ann Arbor

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