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Excessive tension is associated with poorer functional outcomes in primary nerve repair, however its effect on gene expression in regenerating nerves has not been characterized. This research by Kasey Leigh Wood @kasey_leigh_ and her colleagues at the University of Wisconsin Division of Plastic Surgery @uwiscplasticsurgery utilized rat models and RNA-sequencing analysis to determine if there exists a distinct gene expression profile associated with high-tension primary nerve repair. Overall, the gene expression profile of primary nerve repair under high tension was found to be heterogeneous and unpredictable; by contrast, primary nerve repair under minimal tension conferred a predictable gene expression profile similar to that of healthy control nerve. This suggests that the favorable outcomes of primary nerve repair under minimal tension may take root in an optimized gene expression profile, and as such future research into gene expression in regenerating nerves holds the potential to identify therapeutic targets to improve functional outcomes in patients. Primary Nerve Repair - How Does Tension Shape Gene Expression in Regenerating Nerves? Kasey Leigh Wood, BS @kasey_leigh_; Marina I. Adrianzen Fonseca, BS @26marmar; Kirsten A. Gunderson, BS @kagunderson2; Zeeda H. Nkana, BS @zeedankana; Aaron M. Dingle, PhD @2amdingles; Jacqueline S. Israel, MD; Samuel O. Poore, MD, PhD @docpoore University of Wisconsin School of Medicine and Public Health, Division of Plastic Surgery, Madison, Wisconsin

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