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In the operative management of neuromas, translocation of peripheral nerve to the intramedullary canal of bone and implantation into adjacent skeletal muscle are effective approaches that have also provided a robust framework for the development of peripheral neural interfacing technology. The present research by Kasey Leigh Wood @kasey_leigh_ and her colleagues at the University of Wisconsin Division of Plastic Surgery @uwiscplasticsurgery utilized rabbit models and RNA-sequencing analysis to assess and compare differential gene expression in transected nerves housed in bone and tacked to muscle. It was found that the molecular profile of nerve housed in bone was more predictable than that of nerve tacked to muscle. Transposition of nerve into the intramedullary canal may therefore confer superior reliability in neuroma treatment and prophylaxis. Furthermore, as neural interfacing technologies advance, edging closer to the generation of prosthetics with bi-directional feedback ability, these molecular-level changes will become increasingly important considerations. How The Local Environment Induces Differential Gene Expression In Regenerating Nerves After Neurotmesis - Implications For Neuroma Prevention and Neural Interfacing For Prosthetic Control Kasey Leigh Wood, BS @kasey_leigh_; Marina I. Adrianzen Fonseca, BS @26marmar; Kirsten A. Gunderson, BS @kagunderson2; Zeeda H. Nkana, BS @zeedankana; Jacqueline S. Israel, MD; Samuel O. Poore, MD, PhD @docpoore; Aaron M. Dingle, PhD @2amdingles University of Wisconsin School of Medicine and Public Health, Division of Plastic Surgery, Madison, Wisconsin

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