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Secondary lymphedema is a debilitating disease without a cure. 9-cis-Retinoic acid (9-cisRA) has been shown to promote lymphangiogenesis and reduce postsurgical lymphedema in vivo. 9-cisRA is thought to induce its target gene responses by binding to and activating nuclear retinoid X receptors (RXRs). The aim of this study was to determine the role of RXR signaling in 9-cisRA mediated lymphatic endothelial cell migration, tubule formation, proliferation in vitro using lentiviral-based shRNA RXR?-knockdown. RXR? signaling pathway is essential in 9-cis Retinoic acid-induced lymphangiogenesis in human lymphatic endothelial cells. Cynthia Sung BS, Sun Young Park MS, Wan Jiao MD, PhD, Young Kwon Hong PhD, Alex K. Wong MD. Division of Plastic and Reconstructive Surgery of USC, California, Los Angeles.

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