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Apert syndrome can be stratified according to coexisting cranial vault suture synostosis: type I, bicoronal synostosis; type II, pansynostosis; and type III, combination of perpendicular suture synostoses. The differences of skull base and cranial fossae malformation in these three subgroups have been described. As the development of orbital morphology is influenced by the structure of the anterior and middle cranium and skull base, we postulate the orbital and periorbital irregularities vary according to the specific form of cranial vault suture synostosis in Apert syndrome. Xiaona Lu et al from the Yale School of Medicine, evaluated the orbit bony cavity volume, globe volume, retrobulbar soft-tissue volume, and periorbital morphology in Apert syndrome patients of 3 suture type subgroups. Data was compared with age and gender matched controls. They found that different cranial vault suture synostoses generate varied influence on orbital and periorbital development in Apert syndrome. Instead of mitigating the abnormalities resulting from bicoronal synostosis in type I, additional midline suture synostosis worsens the exorbitism due to a more misshaped ethmoid. However, hypoplastic periorbital bone volume was not observed in type III. Find out more about their study in the PSRC 2021 Abstract Supplement of @prsglobalopen Cranial Fossa Volume And Morphology Development In Apert Syndrome Xiaona Lu, MD, PhD @Xiaona.lulu; Antonio J. Forte, MD, PhD; Alexandra Junn, AB; Jacob Dinis, BS; Michael Alperovich, MD; Nivaldo Alonso, MD, PhD; John A. Persing, MD. From the Division of Plastic and Reconstructive Surgery, Yale School of Medicine; Division of Plastic and Reconstructive Surgery, Mayo Clinic Florida; and Department of Plastic Surgery, University of São Paulo.

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