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Emerging next-gen sequencing technologies have provided disruptive advances in our capacity to study complex tissue processes, including wound healing. Michael Januszyk and his co-authors from the Stanford University Department of Surgery and Center for Personal Dynamic Regulomes developed a novel multimodal -omics framework for the comprehensive study of cell populations in heterogeneous tissue in order to track specific cellular subgroups across time and space during wound healing. Dr. Januszyk and his co-authors demonstrated that injury-responsive fibroblast subpopulations differentiate as they proliferate toward the wound center in a radial polyclonal fashion following injury, accompanied by transition from mechano-responsive to pro-fibrotic transcriptional and epigenomic programs. Early targeted abrogation of tissue force sensation disrupted a subset of these transitions and reversed pathologic wound healing in mice, suggesting new clinical strategies aimed at scar reduction. Integrated Spatial Multi-omics Reveals Fibroblast Fate During Wound Healing: A Novel Framework For The Study Of Complex Tissues Michael Januszyk MD PhD; Deshka S Foster MD PhD; Geoffrey C Gurtner MD @GeoffreyGurtner; Howard Y Chang MD PhD; Michael T Longaker MD @LongakerLab Department of Surgery, Stanford University Center for Personal Dynamic Regulomes, Stanford University

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