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The Use Of Hypochlorous Acid Solution Decreased Post-Procedural Erythema For Skin Rejuvenation
Melody Bedrossian, B.S., Cristiano Boneti, MD, Som Kohanzadeh, MD.
Wound Institutes of America, Cedars Sinai Medical Center, Los Angeles, CA, USA.

PURPOSE: Cosmetic surgery and skin rejuvenation techniques are an integral part of daily life, yet the key downside is recovery time. Microneedling works through micro-trauma to the skin to induce collagen formation and healing, but like all other skin treatments, it causes erythema, edema, and in some cases peeling (although on a significantly limited scale compared to traditional ablative laser skin resurfacing).
Hypochlorous Acid (HClO) solution has shown improved outcomes through decreased infection and erythema/inflammation in the wound care setting. We applied it in the cosmetic arena to see if it similarly decreased erythema and thus minimized post-procedural recovery time.
METHODS: A case series of 5 patients prospectively followed to evaluate their responses after micro-needling skin rejuvenation of the face. These patients underwent the procedure in standard fashion with topical anesthetic applied for 30 minutes before the procedure, and then application of moisturizing/hydrating lotion upon completion and thereafter for 48 hours. As part of the study, we added treatment with HClO solution cleansing to half of the face versus half of the face with normal saline. Photos of all patients at 24 and 48 hours were taken and used to compare the HClO treated versus control saline treated half of the face. Each patient performed the procedure 2 times separated by 4 weeks between each treatment.
RESULTS: We found the HClO solution treated side of the face had decreased erythema, edema and pain in 3/5 patients. In all 5/5 on the HClO half of the face there was no incidence of peeling, while in the control normal saline side 2/5 had peeling. We attribute this to HClO solution's ability to maintain a sterile environment without damaging underlying host tissue, in addition to its ability to work through activate of oxygen radicals at the site of injury.
CONCLUSION: HClO solution has had excellent results in our experience in wound care and now we have similarly adopted it in our cosmetic practice, particularly to our skin rejuvenation patients. It helps decrease post-treatment recovery by decreasing erythema, edema, and pain as well as preventing unsightly peeling that can often occur. Moreover, the minimal cost and significant improvement in results (and as a result, in patient satisfaction) convinced us to adopt HClO solution as a part of our standard practice for such patients. We are thus collecting further data to support the use of HClO solution in the cosmetic area.


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