The Use Of Non-invasive Devices To Objectively Measure Changes In Human Facial Skin After Facial Rejuvenation Treatment
Karen B. Lu, BA, Mikaela Kislevitz, BSN, RN, John Hoopman, CMLSO, Yucel Akgul, MD, PhD, Fritz Barton, Jr., MD, Jeffrey M. Kenkel, MD.
University of Texas Southwestern Medical Center, Dallas, TX, USA.
PURPOSE: Non-invasive assessment devices providing objective data regarding various parameters of the skin have been largely available, but its use in clinical studies have been limited. The purpose of this study is to measure facial skin before and after treatment with a 1470-nm/2940-nm laser to determine if non-invasive, objective skin assessment devices can accurately and reliably measure changes in skin texture, tone, water loss, pigmentation, and wrinkles.
METHODS: Twelve patients were enrolled in the study and all patients underwent treatment with a 1470nm/2940nm laser for facial rejuvenation. Prior to treatment, standard and close-up photographs, VISIA images, and 3D images were taken. Non-invasive skin measurements were taken with high resolution ultrasonography, optical coherence tomography (OCT), transepidermal water loss (TEWL), and BTC 2000. The photos and measurements were repeated at follow up on Week 3 and 3 months. All data points were aggregated and analyzed as an average change compared to baseline values.
RESULTS: Our results showed the non-invasive skin assessment devices were able to detect significant changes after treatment in a variety of parameters. Significant improvement was seen in UV spots using the VISIA at 3 weeks and 3 months (p<0.05) and brown spots at 3 months (p <0.05). Using the BTC 2000, our devices were able to detect a statistically significant improvement in elasticity (p<0.05). Attenuation coefficient decreased significantly at 3 weeks (p<0.05) and lastly, blood flow at 0.6mm depth increased significant at 3 weeks (p<0.05).
CONCLUSION: Our pilot study has shown that several non-invasive devices can be used to detect changes in facial skin following an office-based laser treatment. These non-invasive skin assessment devices are able to detect significant changes in skin structure and pigmentation. The VISIA, BTC 2000, OCT, and Dub SkinScanner are useful tools in providing objective measurements and analyzing changes before and after skin rejuvenation treatments.
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