Plastic Surgery Research Council
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PSRC 60th Annual Meeting

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The Anti-Neoplastic Effect of Aminosterol Squalamine on Melanoma
Denver M. Lough, MD, Ph.D1, Damon Cooney, MD, Ph.D2, Shaun Mendenhall, MD3, Joel Reichensperger, BS3, Lisa Cox, BS3, Nicole Cosenza, MS3, Nathan Wetter, MD3, Carrie Harrison, BS3, Michael Neumeister, MD3.
1SIU School of Medicine/ Johns Hopkins, Springfield, IL, USA, 2Johns Hopkins, Baltimore, MD, USA, 3SIU School of Medicine, Springfield, IL, USA.

PURPOSE:
Squalamine, a recently discovered aminosterol, has notably been shown to be effective as both an antibiotic and an inhibitor of angiogenesis. This intrinsic anti-angiogenic effect of squalamine has been studied in the literature for its clinical capacity to reduce cancer progression. Here, we suggest an additional role of squalamine in inducing melanoma destruction via induction of apoptosis and or necrosis of melanotic cells through angiogenic inhibition.
METHODS:
We utilized three model systems: (1) Application of the aminosterol squalamine to a A375 melanoma cell line (2) Application an organotypic 3D melanoma skin model tissue system and to a melanoma murine model in order to determine squalamine’s potential against melanoma viability and progression.
RESULTS:
The addition of squalamine to A375 melanoma cell lines, organotypic 3D melanoma skin model tissue and to a full murine melanoma model showed significant destruction of neoplastic cells with upregulation of both apoptosis and necrosis pathway markers.
CONCLUSION:
Carcinoma of the skin is the most common type of cancer diagnosed in the United States, with the most deadly type being malignant melanoma. The incidence of this disease has continued to rise for the last three decades, with an estimated 70,000 individuals expected to receive a new diagnosis of malignant melanoma in 2014. Using three melanoma models we have shown that this aminosterol is capable of significantly reducing melanoma cell viability and propose a potential therapeutic property in squalamine.


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