Plastic Surgery Research Council
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Primary Lab Contact
Name Tae Hyun Choi, MD, PhD
Title Associate Professor
Phone 82-2-2072-1978
Email psthchoi@snu.ac.kr

Additional Lab Contact
Name Young Min Kim, MS
Title
Phone 82-2-2072-1825
Email nakita-012@hanmail.net

Website http://-
Laboratory Research Institute of Plastic and Reconstructive Surgery (RIPRS)
Lab Location Clinical Research Institute Seoul National University Hospital
101 Daehang-Ro, Jongno-Gu
Seoul, 110-744 Republic of Korea
Lab Category Tissue Engineering
General Lab Setup 6 people working in the lab. 2 MS degree students, 3 PhD. degree Students and 1 post-doctoral degree.
Lab Facilities Cell Biology, Molecular biology (Western blot, ELISA, RT-PCR and etc.)
Animal Facility Yes (Nude-mice, Rat, Rabbit, Pig)
Type of Research Tissue Engineering, Wound Healing
1. Investigator's Name Tae Hyun Choi, MD, PhD
Project Title Preclinical study of fat cells remodelling for the treatment of obesity
Brief Description In 2015, we made an experiment model to differentiated and transplanted BAT (brown adipose tissue). And gained IRB permission to use human fat tissue and stem cell. As a base, we differentiated BAT in vitro and transplanted BAT in vivo in 2016. Firstly, we differentiated BAT and WAT in vitro, and then transplanted cells into mouse model. On a degree of weight variation, compared BAT group with other two groups (WAT group and PBS group), BAT group showed a decrease tendency. But it is meaningless in statistics. LDL cholesterol (LDL-C) is considered the “bad” cholesterol because it contributes to plaque, a thick, hard deposit that can clog arteries and make them less flexible. This condition is known as atherosclerosis. All samples appeared a decrease tendency after injection. But it is meaningless in statistics. In a contract, HDL cholesterol (HDL-C) is considered “good” cholesterol because it helps remove LDL cholesterol from the arteries.. In BAT group, HDL-C raised after inject. In WAT group and PBS group Glucose showed a decrease tendency. BAT group had a sharp decreased of T-CHO in 5 weeks after injection.BAT group had a sharp decreased of T-CHO after injection compared with other 2 groups. And it is meaningful in statistics (P<0.05).On the basis of these statistics, we had a positive result of total cholesterol decrease after injecting brown cell in BAT group. Triglycerides are another type of fat, and they’re used to store excess energy from your diet. High levels of triglycerides in the blood are associated with atherosclerosis. Elevated triglycerides can be caused by overweight and obesity. In the fifth week, WAT group and BAT group had a lower content of TG than PBS group. And it is meaningful in statistics. Even though it has to be confirmed of continues hypothesis, but according to Cholesterol decrease which is meaningful in statistics and the positive effect on a certain degree due to brown cell injection compared with other 2 groups. After experiment, we did biopsy, analyzed the weight of variate organs, and H & E stain, IHC stain (anti-UCP-1 antibody) and measured heart, belly, kidney, stomach and liver. BAT group has a decrease tendency in belly and liver than other 2 groups. In a contract, BAT group has an ascend tendency in heart, kidney and stomach. But it is meaningless in statistics. In the H & E stain and IHC stain, Bat group showed a different pattern with other 2 groups. According to H & E stain, adipose cells in PBS group and WAT group showed normal fat cells morphology. But in BAT group showed little lipid similar to brown adipose tissue (red circle).

2. Investigator's Name Tae Hyun Choi, MD, PhD
Project Title Method for obtaining and fabricating ear model & Biocompatible scaffold for microtia reconstruction
Brief Description A typical method of existing surgeries involves harvesting the ribs, sculpting the cartilage into the shape of the ear, and inserting the sculpted ears. And the operation time may become longer. In order to overcome this, we aim to reduce psychological and physical pain by using 3D scanner and printer to make biocompatible material into ear model and insert it

3. Investigator's Name Tae Hyun Choi, MD, PhD
Project Title Development of delivery carriers for antibiotics to improve the therapeutic efficiency reponding to acidic environments in diabetic abscesses and pneumonia.
Brief Description Development of antibiotics carriers responding to acidic pH in diabetic abscesses or pneumonia and confirmation of therapeutic effect in animal models including subcutaneous abscesses, abdominal abscesses, and pneumonia.

Grants National Research Foundation of Korea, Ministry of Health & Welfare
Opportunity for Student Degree Program Yes  
Research Fellowship Available No
Funding Available National Research Foundation of Korea (New Research grants, Basic Research grants)
Educational or Prior Experience Requirements BS or greater required