Plastic Surgery Research Council
Members Only  |  Contact  | 
Primary Lab Contact
Name W. P. Andrew Lee, MD and Gerald Brandacher, MD

Laboratory Composite Tissue Allotransplantation (CTA) Research Laboratory
Lab Location Johns Hopkins University School of Medicine
Ross Research Building, Suite 749, 720 Rutland Avenue
Baltimore, MD 21205
Lab Category
Lab Facilities 1800 square feet state of the art bench and laboratory space, dedicated small animal microsurgery operating room including three microsurgical workstations; microscopes equipped for teaching and filming; cell and tissue culture laboratory; shared core facilities (confocal microscope, flow cytometry analyzer, flow sorter, ELISA plate reader, Bio-Rad IQ5 quantitative thermocycler, immunohistochemical staining facilities, and histopathological tissue processing and staining).
Animal Facility Yes ( Mice, Rats, Pig)
Type of Research Basic and translational research related to CTA, transplant immunology, stem cell-based immunomodulation and tolerance induction, mechanisms of skin rejection, immune monitoring (cytokine profiling, computational modeling), targeted therapeutics (biologic agents), trans-dermal drug delivery, gene therapy, ischemia reperfusion, nerve regeneration, tissue engineering.
1. Investigator's Name W. P. Andrew Lee, MD and Gerald Brandacher, MD
Brief Description Over the past decade, Composite Tissue Allotransplantation (CTA) such as hand and face transplantation has become a clinical reality and a vivid treatment option for those patients in need suffering from complex tissue injuries or defects not amenable to conventional reconstruction. Despite the fact that early and intermediate functional outcomes are highly encouraging rejection and the need for high-dose multi-drug immunosuppressive treatment continues to be the bane of CTA preventing wider clinical application. Thus, any reconstructive measures to improve these non-life threatening conditions must address a delicate balance of risks and benefits. Therefore, our laboratory focuses on both basic and translational studies related to the unique immunological features of CTA, to investigate the basic mechanisms of an alloimmune response in CTA as well as to develop novel stem cell-based protocols for immunomodulation and tolerance induction after CTA without the need for long-term immunosuppression. Another major emphasis of our laboratory is to establish new treatment options to improve and enhance nerve regeneration and hence functional outcome in CTA using small (mouse, rat) and large animal (pig) models for hind limb transplantation.

Opportunity for Student Degree Program no  
Research Fellowship Available Yes
Funding Available Federal/governmental, Foundations, Corporate, Departmental
Funding Available from Supervisor: )
Full Funding Available: Yes (partial of full funding available
Educational or Prior Experience Requirements MD or PhD required for post-doctoral fellowship, plastic or general surgery residents preferred, medical students will be considered