Plastic Surgery Research Council
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Primary Lab Contact
Name Curtis L. Cetrulo, Jr., MD
Email Curt.Cetrulo@tbrc.mgh.harvard.edu

Laboratory Massachusetts General Hospital-Harvard Medical School Composite Tissue Allotransplantation Laboratory
Lab Location Transplantation Biology Research Center, MGH - East
Building 149, 13th Street, Suite 9019
charlestown, MA 02129
Lab Category
Lab Facilities Preclinical large animal surgery operating suites, animal housing, transplantation research floor
Animal Facility Yes (Swine, non-human primate, mouse)
Type of Research Tolerance approaches for composite tissue allotransplantation
1. Investigator's Name Curtis L. Cetrulo, Jr., MD
Project Title Tolerance approaches for composite tissue allotransplantation
Brief Description The Massachusetts General Hospital-Harvard Medical School Composite Tissue Allotransplantation Laboratory is investigating tolerance induction strategies for composite tissue allografts (CTA) in the immunogenetically-defined MGH miniature swine model and xenotransplantation of genetically-modified porcine skin for severe burn injuries. Current research efforts are directed toward use of mixed hematopoietic chimerism to induce transplantation tolerance to CTA and toward exploring the immunologic mechanisms involved in tolerance and rejection of the skin component of CTA. Additional skin xenotransplantation studies utilize unique genetically-modified Gal knock-out swine that lack the -1,3-galactosyltransferase gene, which codes for the "Gal" cell-surface antigen, associated with hyperacute rejection across xenogenic barriers. Promising data suggests that skin from these swine may provide an alternative to allografts for the immediate coverage of large burns.

Opportunity for Student Degree Program yes  
Research Fellowship Available Yes
Funding Available Departmental, Department of Defense, National Institute of Health
Educational or Prior Experience Requirements