Plastic Surgery Research Council
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Primary Lab Contact
Name Eric C. Liao, MD, PhD
Title Associate Professor of Surgery / Genetics
Phone 617-643-5975
Email cliao@partners.org

Website http://www.massgeneral.org/research/researchlab.aspx?id
Laboratory Harvard Stem Cell Institute / Massachusetts General Hospital
Lab Location Massachusetts General Hospital, Center for Regenerative Medicine
Simches Research Building, 185 Cambridge Street
Boston, MA 02114
Lab Category Clinical Outcomes Research
Fat Grafting & Stem Cell Research
Other: Craniofacial Development and Genetics
General Lab Setup Basic and Translational Research Group: 3 post-doctoral fellows, 2 graduate students, 1 lab manager, 2 technician, 1 facility manager, 1 undergraduate, 1 high school student. Clinical Outcomes Research Group: 1 clinical research fellow, 1 clinical research coordinator, residents and students.
Lab Facilities State of the art molecular biology wet lab, tissue culture system, advanced microscopy, confocal microscopy, micro injectors, zebrafish colony.
Animal Facility Yes (zebrafish, mouse, iPS, human (clinical))
Type of Research Developmental Biology, Genetics, Stem Cell Biology, iPS disease models. Clinical research group, clinical outcomes in breast surgery, cleft lip and palate surgery.
1. Investigator's Name Eric C. Liao, MD, PhD
Project Title Developmental Genetics of Craniofacial Development, Clinical outcomes research
Brief Description Our current projects leverage advances in genomics, gene editing, developmental biology and chemical biology to translate fundamental biological insights to clinical impact. 1. Functional genomics: we employ animal models to rapidly examine the function of novel human candidate genes and gene variants in craniofacial development. 2. Craniofacial development: we examine the interaction of genes in the Wnt pathway in how they regulate palate and mandibular morphogenesis. 3. IRF6 downstream pathways and function in development: we employed a novel irf6 mutant model to uncover target genes of transcription factor IRF6 and how environmental factors intersect with IRF6 in cleft pathogenesis. We also engineered a high-throughput platform to carry out small molecule screen using the irf6-/- mutants, to discover drugs that can mitigate cleft pathogenesis. We also carry out clinical outcomes research, examining topics in breast surgery and cleft lip and palate repairs.

Opportunity for Student Degree Program yes, students at various levels have completed research in our laboratory. We have hosted students for HHMI MD Fellowship, PhD degree, MD, PhD degree.  
Research Fellowship Available Yes
Funding Available NIH, Shriners, PSF, Departmental
Educational or Prior Experience Requirements MD or PhD required, strong communication skills. Experience is molecular biology is strongly desired.  
Additional Details Research Fellowship Available: Yes, 2-year tenure unless candidate has own funding