Plastic Surgery Research Council
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Primary Lab Contact
Name Elof Eriksson, MD, PhD
Email eeriksson@partners.org

Laboratory Tissue Repair & Gene Therapy
Lab Location Brigham and Women's Hospital
15th floor of the Thorn Research Building
Boston, MA
Lab Category
Lab Facilities The laboratory is fully equipped with microscopes, sinks, and sterile hoods for tissue culture, as well as sterile storage space for tissue and reagents. The laboratory is located on the 15th floor of the Thorn Research Building, within the Brigham and Women's Hospital (BWH) campus.
Animal Facility Yes (Pigs, mice, rats)
Type of Research Tissue Engineering, Tissue Repair, Skin Transplantation
1. Investigator's Name Elof Eriksson, MD, PhD
Project Title Transplantation of skin particles to regenerate full-thickness wounds
Brief Description By enclosing the wound in a sealed transparent chamber, transplantation of individual cells, groups of cells or skin particles to the wound can be carried out. Our laboratory was first to transplant both single cell suspensions and minced skin to this tissue culture-like wound environment. Transplantation of cells and skin particles is one of the methodologies that are being used in the laboratory (Vogt et al. 1994, PNAS, Svensjo et al. 2002, J Surg Res) in order to accelerate healing and minimize donor sites. Current experiments deal with both wounds that heal normally and that have impaired healing. We are particularly interested in diabetic wound healing.

2. Investigator's Name Elof Eriksson, MD, PhD
Project Title vivo gene transfer to facilitate healing of full-thickness wounds
Brief Description Our research methodology spans a wide spectrum from molecular biology, cell biology, tissue engineering experimentation, small and large in vivo experiments. Therefore we use a sealed chamber to control and study the wound environment. This chamber functionally becomes an in vivo incubator. With use of this model, the wound micro-environment can readily be monitored and modified in a specific fashion like a tissue culture in vivo. Thus, the wound healing process can be modulated repetitively by targeted delivery of therapeutic genes into the wound microenvironment using and assessing various in vivo and ex vivo gene delivery techniques as well as daily wound fluid collection, monitoring of wound contraction, histology and immunohistochemistry.

3. Investigator's Name Elof Eriksson, MD, PhD
Project Title Decellularization of natural vascularized bioscaffolds
Brief Description The ultimate biomaterial scaffold should closely mimic the native extracellular matrix with all its complex matrix bound signals and environmental aspects. Humbled by the fact that manufacturing such a scaffold is too large of an undertaking, our approach relies of the decellularization of vascularized pedicles, thereby harnessing the native regenerative capacity inherent in the tissue. The scaffold is non-immunogenic and can be reseeded with autologous cells, and microsurgically implanted to recapitulate normal tissue function. Current experiments involve elucidating optimal decellularization parameters, optimal cell sources and testing the physiological properties of the engineered tissue construct.

Opportunity for Student Degree Program no  
Research Fellowship Available
Funding Available Foundations, governmental, corporate
Full Funding Available: Yes
Educational or Prior Experience Requirements Medical Student, MD or PhD