Plastic Surgery Research Council
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Primary Lab Contact
Name Michael W. Neumeister, MD
Title Professor and Chair - Department of Surgery
Phone 217-545-7018

Laboratory Microsurgery, Tissue Engineering, Burn and Wound Healing
Lab Location Southern Illinois University School of Medicine (SIUSOM)
801N. Rutledge Street
Springfield, IL 62794
Lab Category Clinical Outcomes Research
Composite Tissue Allotransplantation (CTA)
Fat Grafting & Stem Cell Research
Microsurgery/Flap Physiology
Tissue Engineering
Tumor Immunology/Cancer Biology
Wound Healing
General Lab Setup One full time researcher dedicated to cell culture One full time researcher dedicated to bench assays Two full time researchers dedicated to leading research projects and performing all animal surgeries including microsurgery.
Lab Facilities The Institute for Plastic Surgery has approximately 2400 square feet of laboratory space in the 801 building of SIU School of Medicine. 1200 square feet are dedicated to rodent microsurgery with 4 operating microsurgery microscopes (Leica Wild 650, Leica M295, Zeiss F125, and Leica Wild M680 equipped with a Sony PDW-10MD video camera with one 31 inch monitor and one 46 inch monitor. 800 square feet of lab space are dedicated to molecular biology and other bench assays. Equipment includes a Biorad C1000 Thermocycler, Fisher Scientific Isotemp hybridization oven, and Baker Sterile Gard BCL2 cell culture hood. The remaining 382 square feet are dedicated to tissue engineering and cell culture. Equipment includes a BSLII biosafety hood, four CO2 controlled Forma Series II incubators, an Olympus CK40 inverted light microscope and an Olympus IX 51 inverted fluorescent microscope with Infinity Lite camera attachment. The Core facility at SIU has a Becton-Dickinson FACSAria II high-speed cell sorter, ABI 1 Step Plus Real Time PCR machines, Bioluminescence Imager, Leica LSCM confocal microscope, fluorescent microscopes, Faxitron X-ray machine, Syngene G:Box iChemi XT chemiluminescence imaging system, Hitachi S-3000 scanning electron microscope, and Hitachi H-7000 transmission electron microscope.
Animal Facility Yes (Small and large animal on site)
Type of Research Microsurgery; burn and wound healing; ischemia reperfusion; tissue engineering; gene transfection; stem cells; composite tissue allotransplantation; bioengineering; biomechanics; hyperbaric oxygen
1. Investigator's Name Michael W. Neumeister, MD
Project Title The Development of a Plastic and Reconstructive Surgical Research Division and Center for Tissue Engineering at Memorial Medical Center
Brief Description This funding will be used to establish a joint SIU/MMC Surgical Research Core where discarded human skin and/or tissue after burn wound debridement can be harvested, tissue banked, clinically catalogued, cultured and assembled into hybrid autografts. These unique hybrid autografts will, for the first time, utilize the patient’s own isolated autologous progenitor cells in combination with an acellular patient-derived matrix system from the wound bed itself. This engineered hybrid autograft will provide patients with a self-assembled skin substitute that provides both a rapid tissue barrier as well as immunomodualtory function.

2. Investigator's Name Michael W. Neumeister, MD
Project Title ADSC Transplantation Potentiates Tissue Reorganization and Repair
Brief Description Interest in adipose-derived mesenchymal stem cells (ADSC) in promoting tissue regeneration is currently under investigation. However, its effect on skin regeneration during tissue expansion in the setting of a radiated field has yet to be determined. We hypothesize that ADSC transplantation will decrease tissue damage and enhance the efficiency of tissue expansion in animals treated with radiotherapy.

3. Investigator's Name Michael Neumeister, MD
Project Title A Two-Part Study of BOTOX® Therapy for Ischemic Digits
Brief Description This is a 2-part pilot study examining the short- and long-term efficacy of botulinum toxin type-A [Btx-A (BOTOX®, Allergan, Inc.)] in relieving pain due to Raynaud’s disease/phenomenon. Primary objective is to examine the short-term effectiveness of Btx-A injection compared to placebo in treating pain associated with digit ischemia due to Raynaud’s disease/phenomenon. Secondary objective is to describe the long-term efficacy of Btx-A injection in treating pain associated with digit ischemia due to Raynaud’s disease by measuring patient satisfaction and quality-of-life changes over time. Funded by Memorial Medical Center Foundation and American Society for Surgery of the Hand.

Grants Our Lab is currently funded by Memorial Medical Center Foundation, Plastic Surgery Foundation,American Foundation for Surgery of the Hand, and American Society for Surgery of the Hand and Department of Surgery at SIU.
Opportunity for Student Degree Program MS and PhD in related areas from SIUSOM  
Research Fellowship Available Yes
Funding Available State grants, University grants, non-profit foundation grants and endowment, society and association grants
Educational or Prior Experience Requirements Full assessment of credentials required