Plastic Surgery Research Council
Members Only  |  Contact  | 
Primary Lab Contact
Name Alex K. Wong, MD
Title Associate Professor of Surgery
Phone 323-442-7920

Laboratory USC Plastic and Reconstructive Surgery Laboratory
Lab Location Keck School of Medicine of USC
2250 Alcazar Street, CSA 222
Los Angeles, CA 90033
Lab Category Clinical Outcomes Research
Fat Grafting & Stem Cell Research
Microsurgery/Flap Physiology
Tissue Engineering
Wound Healing
Other: Lymphangiogenesis and Lymphedema
General Lab Setup 1-2 post-doctoral fellows; 1-3 medical or graduate students; lab technician
Lab Facilities Tissue culture, molecular biology, operating surgical microscope, access to core facilities
Animal Facility Yes (Mice, Rats, swine)
Type of Research Translational and basic research using animal model systems and patient tissue
1. Investigator's Name Alex K. Wong, MD
Project Title Pharmacologic prevention of secondary lymphedema

2. Investigator's Name Alex K. Wong, MD
Project Title Molecular biology and translational approaches to radiation induced delayed wound healing

3. Investigator's Name Alex K. Wong, MD
Project Title Microsurgical vascularized tissue and lymph node flap physiology

Grants NIH, Private foundation, Industrial grants, PSF, CIRM
Opportunity for Student Degree Program Yes  
Research Fellowship Available Yes
Funding Available Depending on qualifications
Educational or Prior Experience Requirements MD or PhD  
Additional Details Dr. Alex K. Wong is an Associate Professor of Surgery in the Division of Plastic and Reconstructive Surgery. He is the Director of the USC Microvascular Surgery Fellowship Program, Director of Basic, Translation, and Clinical Research, and Director for Medical Student Education. Dr. Wong performs aesthetic surgery of the face, breast, and body. He has a special interest in breast augmentation with implants and autologous fat grafting. His reconstructive practice is focused on microsurgical free tissue transfer for the management of complex wounds, post-oncologic reconstruction, abdominal wall reconstruction, and lymphedema surgery. Dr. Wong has attending staff appointments at Keck University Hospital of USC, LAC+USC Medical Center, Huntington Memorial Hospital, and Garfield Medical Center. Some of Dr. Wong's many qualifications include: Member of the Society of University Surgeons, American Society of Plastic Surgeons, American Society for Reconstructive Microsurgery, World Society for Reconstructive Microsurgery, and Plastic Surgery Research Council. He is a Diplomat of the American Board of Plastic Surgery and Fellow of the American College of Surgeons. Dr. Wong has been named one of Pasadena Magazine's Top Doctors for every year since 2010, and is on the list of SuperDoctors/Los Angeles Magazine. As a member of the full time Keck School of Medicine USC faculty, Dr. Wong teaches and mentors the next generation of doctors and plastic surgeons. He serves as the Director of Plastic Surgery Visiting Clerkship at the Keck School of Medicine. In addition to his clinical practice, Dr. Wong directs a research laboratory with focus areas in lymphedema, adult-derived stem cells and novel biologics for wound healing, molecular pathogenesis of silicone breast implant capsular contracture, and microvascular flap physiology. Dr. Wong has received multiple grants and awards from organizations such as the National Institutes of Health, Howard Hughes Medical Institute, Plastic Surgery Educational Foundation, American Society for Maxillofacial Surgery, Wright Foundation, Whittier Foundation, American Cancer Society, and Southern California-Clinical Translational Science Institute (SC-CTSI). His work has been published in a variety of high impact peer reviewed journals. Prior to joining the faculty at USC, Dr. Wong completed his Fellowship training at the NYU Institute of Reconstructive Plastic Surgery and completed his formal Plastic Surgery residency at the University of Pittsburgh. Dr. Wong received his medical degree from Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology and is an honors graduate of the College of Arts and Sciences of Cornell University. References: 1: Choi D, Park E, Jung E, Cha B, Lee S, Yu J, Kim PM, Lee S, Hong YJ, Koh CJ, Cho CW, Wu Y, Jeon NL, Wong AK, Shin L, Kumar SR, Bermejo-Moreno I, Srinivasan RS, Cho IT, Hong YK. Piezo1 incorporates mechanical force signals to genetic program that governs lymphatic valve development and maintenance. JCI Insight. 2019 Jan 24. pii: 125068. doi: 10.1172/jci.insight.125068. [Epub ahead of print] PubMed PMID: 30676326. 2: Perrault DP, Lee GK, Park SY, Lee S, Choi D, Jung E, Seong YJ, Park EK, Sung C, Yu R, Bouz A, Pourmoussa A, Kim SJ, Hong YK, Wong AK. Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis. Lymphat Res Biol. 2019 Jan 16. doi: 10.1089/lrb.2018.0035. [Epub ahead of print] PubMed PMID: 30648916. 3: Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 Jun 20;7(1):3876. doi: 10.1038/s41598-017-03614-y. PubMed PMID: 28634413; PubMed Central PMCID: PMC5478660. 4: Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 3;127(4):1225-1240. doi: 10.1172/JCI87442. Epub 2017 Mar 6. PubMed PMID: 28263185; PubMed Central PMCID: PMC5373895. 5: Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28;120(9):1426-1439. doi: 10.1161/CIRCRESAHA.116.309548. Epub 2017 Feb 6. PubMed PMID: 28167653; PubMed Central PMCID: PMC6300148. 6: Bramos A, Perrault D, Yang S, Jung E, Hong YK, Wong AK. Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid. Ann Surg. 2016 Aug;264(2):353-61. doi: 10.1097/SLA.0000000000001525. PubMed PMID: 26655920.