|Primary Lab Contact
||Alex K. Wong, MD
||Associate Professor of Surgery
||USC Plastic and Reconstructive Surgery Laboratory
||Keck School of Medicine of USC
2250 Alcazar Street, CSA 222
Los Angeles, CA 90033
||Clinical Outcomes Research
Fat Grafting & Stem Cell Research
Other: Lymphangiogenesis and Lymphedema
|General Lab Setup
||1-2 post-doctoral fellows; 1-3 medical or graduate students; lab technician
||Tissue culture, molecular biology, operating surgical microscope, access to core facilities
||Yes (Mice, Rats, swine)
|Type of Research
||Translational and basic research using animal model systems and patient tissue
||Alex K. Wong, MD
||Pharmacologic prevention of secondary lymphedema
||Alex K. Wong, MD
||Molecular biology and translational approaches to radiation induced delayed wound healing
||Alex K. Wong, MD
||Microsurgical vascularized tissue and lymph node flap physiology
||NIH, Private foundation, Industrial grants, PSF, CIRM
|Opportunity for Student Degree Program
|Research Fellowship Available
||Depending on qualifications
|Educational or Prior Experience Requirements
||MD or PhD
||Dr. Alex K. Wong is an Associate Professor of Surgery in the Division of Plastic and Reconstructive Surgery. He is the Director of the USC Microvascular Surgery Fellowship Program, Director of Basic, Translation, and Clinical Research, and Director for Medical Student Education.
Dr. Wong performs aesthetic surgery of the face, breast, and body. He has a special interest in breast augmentation with implants and autologous fat grafting. His reconstructive practice is focused on microsurgical free tissue transfer for the management of complex wounds, post-oncologic reconstruction, abdominal wall reconstruction, and lymphedema surgery. Dr. Wong has attending staff appointments at Keck University Hospital of USC, LAC+USC Medical Center, Huntington Memorial Hospital, and Garfield Medical Center.
Some of Dr. Wong's many qualifications include: Member of the Society of University Surgeons, American Society of Plastic Surgeons, American Society for Reconstructive Microsurgery, World Society for Reconstructive Microsurgery, and Plastic Surgery Research Council. He is a Diplomat of the American Board of Plastic Surgery and Fellow of the American College of Surgeons. Dr. Wong has been named one of Pasadena Magazine's Top Doctors for every year since 2010, and is on the list of SuperDoctors/Los Angeles Magazine.
As a member of the full time Keck School of Medicine USC faculty, Dr. Wong teaches and mentors the next generation of doctors and plastic surgeons. He serves as the Director of Plastic Surgery Visiting Clerkship at the Keck School of Medicine.
In addition to his clinical practice, Dr. Wong directs a research laboratory with focus areas in lymphedema, adult-derived stem cells and novel biologics for wound healing, molecular pathogenesis of silicone breast implant capsular contracture, and microvascular flap physiology. Dr. Wong has received multiple grants and awards from organizations such as the National Institutes of Health, Howard Hughes Medical Institute, Plastic Surgery Educational Foundation, American Society for Maxillofacial Surgery, Wright Foundation, Whittier Foundation, American Cancer Society, and Southern California-Clinical Translational Science Institute (SC-CTSI). His work has been published in a variety of high impact peer reviewed journals.
Prior to joining the faculty at USC, Dr. Wong completed his Fellowship training at the NYU Institute of Reconstructive Plastic Surgery and completed his formal Plastic Surgery residency at the University of Pittsburgh. Dr. Wong received his medical degree from Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology and is an honors graduate of the College of Arts and Sciences of Cornell University.
1: Choi D, Park E, Jung E, Cha B, Lee S, Yu J, Kim PM, Lee S, Hong YJ, Koh CJ,
Cho CW, Wu Y, Jeon NL, Wong AK, Shin L, Kumar SR, Bermejo-Moreno I, Srinivasan
RS, Cho IT, Hong YK. Piezo1 incorporates mechanical force signals to genetic
program that governs lymphatic valve development and maintenance. JCI Insight.
2019 Jan 24. pii: 125068. doi: 10.1172/jci.insight.125068. [Epub ahead of print]
PubMed PMID: 30676326.
2: Perrault DP, Lee GK, Park SY, Lee S, Choi D, Jung E, Seong YJ, Park EK, Sung
C, Yu R, Bouz A, Pourmoussa A, Kim SJ, Hong YK, Wong AK. Small Peptide Modulation
of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis.
Lymphat Res Biol. 2019 Jan 16. doi: 10.1089/lrb.2018.0035. [Epub ahead of print]
PubMed PMID: 30648916.
3: Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A,
Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W,
Kwong L, Hong YK, Wong AK. Topical Fibronectin Improves Wound Healing of
Irradiated Skin. Sci Rep. 2017 Jun 20;7(1):3876. doi: 10.1038/s41598-017-03614-y.
PubMed PMID: 28634413; PubMed Central PMCID: PMC5478660.
4: Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H,
Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh
CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote
lymphatic sprouting. J Clin Invest. 2017 Apr 3;127(4):1225-1240. doi:
10.1172/JCI87442. Epub 2017 Mar 6. PubMed PMID: 28263185; PubMed Central PMCID:
5: Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G,
Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong
YK. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to
Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr
28;120(9):1426-1439. doi: 10.1161/CIRCRESAHA.116.309548. Epub 2017 Feb 6. PubMed
PMID: 28167653; PubMed Central PMCID: PMC6300148.
6: Bramos A, Perrault D, Yang S, Jung E, Hong YK, Wong AK. Prevention of
Postsurgical Lymphedema by 9-cis Retinoic Acid. Ann Surg. 2016 Aug;264(2):353-61.
doi: 10.1097/SLA.0000000000001525. PubMed PMID: 26655920.