Plastic Surgery Research Council
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Primary Lab Contact
Name Chan Yeong Heo
Title MD, PhD
Phone +82-31-787-7222
Email lionheo@snu.ac.kr

Website http://www.snubh.org, http://en.medicine.snu.ac.kr
Laboratory Biointegration Research Laboratory
Lab Location 82, Gumi-ro, 173 Beon-gil, Bundang-gu,
Seoul National University Bundang Hospital
Gyeonggi-do, 463-707 Republic of Korea
Lab Category Clinical Outcomes Research
Fat Grafting & Stem Cell Research
Microsurgery/Flap Physiology
Tissue Engineering
Wound Healing
Other: Biointegratikon of Medical Devices
General Lab Setup http://blog.naver.com/lionheo http://www.ramtechnologies.co.kr
Lab Facilities https://msri.snubh.org/index.do
Animal Facility Yes (https://msri.snubh.org/preClinicExp/intro/facility.do)
Type of Research Biointegration refers to the interconnection between a biomedical device and the recipient tissue. In many implant devices, the lack of proper biointegration can cause device failure and potentially serious medical problems. This review summarizes the recent progress in surface chemistry, drug delivery and antifouling methods to improve the biointegration of implants. Much progress has been made as our understanding of biological systems and material properties expands and as new technologies become available. This article addresses methods of enhancing biointegration by means of modifying implant surface chemistry and by drug-delivery approaches.
1. Investigator's Name Park S, Park M, Kim BH, Lee JE, Park HJ, Lee SH, Park CG, Kim MH, Kim R, Kim EH, Heo CY, Choy YB
Project Title Acute suppression of TGF- with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants.
Brief Description We propose the acute, local suppression of transforming growth factor beta (TGF-), a major profibrotic cytokine, to reduce fibrosis around silicone implants. To this end, we prepared silicone implants that were able to release tranilast, a TGF- inhibitor, in a sustained manner for 5days or 15days. We performed histologic and immunohistochemical analyses for 12weeks after the implantation of the implants in living rats. The capsule thicknesses and collagen densities significantly decreased compared with those around the non-treated silicone implants. Notably, early suppression of TGF- affected the fibrogenesis that actually occurs at the late stage of wound healing. This change may be ascribed to the decrease in monocyte recruitment mediated by early TGF- during the acute inflammatory reaction. Thus, a significant decrease in differentiated macrophages was observed along with a decrease in the quantity of TGF- and fibroblasts during the subsequent inflammation stage; these changes led to a diminished fibrotic capsule formation.(J Control Release. 2015 Feb 28;200:125-37)

2. Investigator's Name Lee JE, Park S, Park M, Kim MH, Park CG, Lee SH, Choi SY, Kim BH, Park HJ, Park JH, Heo CY, Choy YB.
Project Title Surgical suture assembled with polymeric drug-delivery sheet for sustained, local pain relief.
Brief Description Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery sutures adversely influenced the mechanical strength of the suture itself - strength that is essential for successful wound closure. Thus, it is not easy to control drug delivery with sutures, and the drug-delivery surgical sutures available for clinical use are now limited to anti-infection roles. Here, we demonstrate a surgical suture enabled to provide controlled delivery of a pain-relief drug and, more importantly, we demonstrate how it can be fabricated to maintain the mechanical strength of the suture itself. For this purpose, we separately prepare a drug-delivery sheet composed of a biocompatible polymer and a pain-relief drug, which is then physically assembled with a type of surgical suture that is already in clinical use. In this way, the drug release profiles can be tailored for the period of therapeutic need by modifying only the drug-loaded polymer sheet without adversely influencing the mechanical strength of the suture. The drug-delivery sutures in this work can effectively relieve the pain at the surgical site in a sustained manner during the period of wound healing, while showing biocompatibility and mechanical properties comparable to those of the original surgical suture in clinical use.(Acta Biomater. 2013 Sep;9(9):8318-27)

3. Investigator's Name Min KH, Kim JH, Park HJ, Chung HS, Heo CY.
Project Title The skin-tightening effects of 1,444-nm Nd:YAG laser on human skin: an in vivo study.
Brief Description The 1,444-nm Nd:YAG laser was developed to improve the removal of fat cells and to affect the underlying dermis with the aim of skin tightening. We conducted this study to evaluate whether this laser is effective in tightening the skin and causing histological alterations to dermal collagen fibers, fibroblasts, mucopolysaccharides, and elastin. In a 38-year-old patient who was scheduled to undergo elective abdominoplasty, we subdermally performed laser-assisted treatment with the 1,444-nm Nd:YAG laser using different power settings over periods of 3 months and 1 month and prior to surgery. Postoperatively, we evaluated the skin-tightening effect through histopathologic examination. On histopathology examination, the thickness of the dermis had gradually increased following the 3-month treatment with laser irradiation. In the treatment groups on the abdomen, the collagen fibers were arranged in a more parallel pattern and became denser than those in the control group. Likewise, fibroblast proliferation and the levels of mucopolysaccharides and elastin were higher in the treatment groups than in the control group. The 1,444-nm Nd:YAG laser was effective in promoting the remodeling of the dermis and the regeneration of collagen fibers. As such, the 1,444-nm Nd:YAG laser could be used for skin tightening in addition to its function in lipolysis.(Aesthetic Plast Surg. 2014 Jun;38(3):585-91)

Grants Bsiointegration Research Institute is offering one-year faculty research fellowships to surgeons entering academic careers in plastic surgery. The fellowship is to assist a surgeon in the establishment of a new and independent research program.
Opportunity for Student Degree Program International fellowship, MS & PhD Program  
Research Fellowship Available Yes
Funding Available Research funds with stipend salary
Educational or Prior Experience Requirements Contact to Lab Director.