Plastic Surgery Research Council
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Primary Lab Contact
Name Lars Steinstraesser, MD, FACS, FAAP
Title Heisenberg-Professor and Chair, Dept. Plastic Surgery, University Oldenburg
Phone +49 441236917
Email lars.steinstraesser@uni-oldenburg.de

Website http://www.uni-oldenburg.de
Laboratory Plastic Surgery Oldenburg
Lab Location Plastic Surgery Oldenburg
Steinweg 13-17
Oldenburg, 26131 Germany
Lab Category Clinical Outcomes Research
Composite Tissue Allotransplantation (CTA)
Fat Grafting & Stem Cell Research
Ischemia/Reperfusion
Microsurgery/Flap Physiology
Tissue Engineering
Tumor Immunology/Cancer Biology
Wound Healing
General Lab Setup number of people working in the lab 5-10 in close collaboration with the faculty of biology and chemistry
Lab Facilities 250 m2 fully equiped laboratory space. Full spectrum of cell and tissue culture, in-situ Hybridization, microscopy, histology, RNA, DNA, protein analysis, immunological assays, microcirculation, gene transfer, microbiology, molecular biology, in vivo microscopy, Wet lab space for biochemistry, molecular biology and immunological assays; facilities for EM and histology, computerized histomorphometry; Real time PCR, microarray and high throughput proteomics; small animal surgical facilities with complete animal surgery operating rooms and instrumentation.
Animal Facility Yes (Rodents (rats, mice))
Type of Research Innate immunity, Infection, gene transfer, genomics, composite tissue allotransplantation, microcirculation, microbiology, molecular biology, nerve regeneration, stem cell research, sepsis, soft tissue sarcomas, tissue engineering, proteomics, wound healing
1. Investigator's Name Lars Steinstraesser, MD FACS, FAAPS
Project Title Role of the innate immune system in soft tissue sarcoma
Brief Description Soft tissue sarcomas (STSs) are a heterogeneous group of rare, mesenchymal tumors. Treatment with common chemotherapeutic drugs is consistently associated with low response rates and high rates of adverse toxic effects. Host defense peptides (HDPs) are used as part of innate immunity, and many of them act by directly lysing the target cell membrane. Studies have demonstrated high selectivity of HDP analogs against malignant cells because of a relative abundance of negative charges in malignant cell membranes, compared to normal cells.

Grants German Research Foundation (DFG), European Union, Research Pool Carl von Ossietzky University Oldenburg, Industry
Opportunity for Student Degree Program BSc, Msc, MD, PhD, Dr. med., Habilitation  
Research Fellowship Available Yes
Funding Available Yes
Educational or Prior Experience Requirements Medical Students (BSc, MSc), Residents (MD, PhD)  
Additional Details Research in the field of wound healing, gene transfer, stem cell therapy, and tissue engineering, inflammation and microcirculation and sarcoma. We aim to develop new insights into regnerative processes, inflammation and sarcoma development. Currently, there are several ongoing innovative projects in the field of plastic surgery research